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  2. Modified-release dosage - Wikipedia

    en.wikipedia.org/wiki/Modified-release_dosage

    Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage).

  3. Stimuli-responsive drug delivery systems - Wikipedia

    en.wikipedia.org/wiki/Stimuli-responsive_drug...

    The highly targeted and controlled release ability, as well as their broad applications, make pH-responsive drug delivery systems some of the most well-researched and sought after clinical solutions in stimuli-responsive drug delivery. [3]

  4. Drug delivery - Wikipedia

    en.wikipedia.org/wiki/Drug_delivery

    Since the approval of the first controlled-release formulation in the 1950s, research into new delivery systems has been progressing, as opposed to new drug development which has been declining. [13] [14] [15] Several factors may be contributing to this shift in focus. One of the driving factors is the high cost of developing new drugs.

  5. Osmotic-controlled release oral delivery system - Wikipedia

    en.wikipedia.org/wiki/Osmotic-controlled_Release...

    Osmotic release systems have a number of major advantages over other controlled-release mechanisms. They are significantly less affected by factors such as pH, food intake, GI motility, and differing intestinal environments. Using an osmotic pump to deliver drugs has additional inherent advantages regarding control over drug delivery rates.

  6. Pharmaceutical formulation - Wikipedia

    en.wikipedia.org/wiki/Pharmaceutical_formulation

    In other sustained release formulations the matrix swells to form a gel through which the drug exits. Another method by which sustained release is achieved is through an osmotic controlled-release oral delivery system, where the active compound is encased in a water-permeable membrane with a laser drilled hole at one end. As water passes ...

  7. Drug carrier - Wikipedia

    en.wikipedia.org/wiki/Drug_carrier

    Drug carriers are primarily used to control the release of drugs into systemic circulation. This can be accomplished either by slow release of a particular drug over a long period of time (typically diffusion ) or by triggered release at the drug's target by some stimulus, such as changes in pH, application of heat, and activation by light.

  8. Targeted drug delivery - Wikipedia

    en.wikipedia.org/wiki/Targeted_drug_delivery

    The conventional drug delivery system is the absorption of the drug across a biological membrane, whereas the targeted release system releases the drug in a dosage form. The advantages to the targeted release system is the reduction in the frequency of the dosages taken by the patient, having a more uniform effect of the drug, reduction of drug ...

  9. Pharmaceutical engineering - Wikipedia

    en.wikipedia.org/wiki/Pharmaceutical_engineering

    The result was a continuous release of the drug as it travelled through the intestinal tract. Although modern day research focuses on extending the controlled release timescale to the order of months, once-a-day and twice-a-day pills are still the most widely utilized controlled drug release method. [8]