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  2. Cytokine storm - Wikipedia

    en.wikipedia.org/wiki/Cytokine_storm

    Cytokine storm syndrome is a diverse set of conditions that can result in a cytokine storm. Cytokine storm syndromes include familial hemophagocytic lymphohistiocytosis , Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis, systemic or non-systemic juvenile idiopathic arthritis –associated macrophage activation syndrome , NLRC4 ...

  3. Cytokine release syndrome - Wikipedia

    en.wikipedia.org/wiki/Cytokine_release_syndrome

    In immunology, cytokine release syndrome (CRS) is a form of systemic inflammatory response syndrome (SIRS) that can be triggered by a variety of factors such as infections and certain drugs. [3] It refers to cytokine storm syndromes (CSS) [ 4 ] and occurs when large numbers of white blood cells are activated and release inflammatory cytokines ...

  4. Hemophagocytic lymphohistiocytosis - Wikipedia

    en.wikipedia.org/wiki/Hemophagocytic_lymphohist...

    It is a life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of benign lymphocytes and macrophages that secrete high amounts of inflammatory cytokines. It is classified as one of the cytokine storm syndromes. There are inherited and non-inherited (acquired) causes of HLH.

  5. Cytokine - Wikipedia

    en.wikipedia.org/wiki/Cytokine

    Over-secretion of cytokines can trigger a dangerous cytokine storm syndrome. Cytokine storms may have been the cause of severe adverse events during a clinical trial of TGN1412. Cytokine storms are also suspected to have been the main cause of death in the 1918 "Spanish Flu" pandemic. Deaths were weighted more heavily towards people with ...

  6. Catastrophic antiphospholipid syndrome - Wikipedia

    en.wikipedia.org/wiki/Catastrophic_antiphospho...

    Anticoagulation is given to stop the thrombophilic state, and it promotes the clot breakdown, while steroids downregulate the cytokine storm that is thought to be responsible for systemic inflammatory response syndrome (SIRS). [13] Additional steps may have to be taken to manage circulatory problems, kidney failure, and respiratory distress.

  7. Sepsis - Wikipedia

    en.wikipedia.org/wiki/Sepsis

    The early phase of sepsis characterized by excessive inflammation (sometimes resulting in a cytokine storm) may be followed by a prolonged period of decreased functioning of the immune system. [ 31 ] [ 8 ] Either of these phases may prove fatal.

  8. Langerhans cell histiocytosis - Wikipedia

    en.wikipedia.org/wiki/Langerhans_cell_histiocytosis

    Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive secretion of multiple cytokines by dendritic cells and bystander-cells (a phenomenon known as cytokine storm) in the lesional tissue, favorable prognosis and relatively good survival rate in patients without organ dysfunction or risk ...

  9. Thirumala-Devi Kanneganti - Wikipedia

    en.wikipedia.org/wiki/Thirumala-Devi_Kanneganti

    Beyond her studies on IL-1 family members, her recent work on cytokine storm established TNF and IFN-γ as the key upstream cytokines that cause inflammatory cell death (PANoptosis), tissue and organ damage, and mortality, and she has suggested that strategies to target these cytokines or other molecules in their signaling pathway should be ...