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Lubiprostone is a bicyclic fatty acid [15] derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements.
Linaclotide, (sold under the brand name Linzess in the US and Mexico, ... Between 1% and 10% of people have decreased appetite, dehydration, low potassium, ...
Plecanatide has been shown to be safe and effective. It has shown to be at least equally as effective as its main competitor, linaclotide (brand name Linzess), but has been shown to have a lower rate of diarrhea as an adverse drug reaction. [10]
U.S. Food and Drug Administration Grants Priority Review Status to AMITIZA ® (lubiprostone) Submission Seeking Approval for Treatment of Opioid-induced Constipation BETHESDA, Md. & DEERFIELD, Ill ...
Ironwood Pharmaceuticals Provides Second Quarter 2013 Investor Update Second quarter LINZESS ® (linaclotide) net product sales of $28.8 million, as reported by Forest Laboratories, Inc. CAMBRIDGE ...
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