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Anorexia, skin lesions, hair loss, hepatosplenomegaly, papilloedema, bleeding, general malaise, pseudotumor cerebri, and death may also occur. [28] Similar effects occur with other retinoids, except for 13-cis retinoic acid and its derivatives, such as adapalene.
Three medications have evidence to support their use in male pattern hair loss: finasteride, dutasteride and minoxidil. [15] They typically work better to prevent further hair loss than to regrow lost hair. [15] They may be used together when hair loss is progressive or further regrowth is desired after 12 months. [16]
Adapalene, sold under the brand name Differin among others, is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. [6] Studies have found adapalene is as effective as other retinoids, while causing less irritation. [7]
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