Search results
Results From The WOW.Com Content Network
Establishment of the forelimb field (but not hindlimb field) requires retinoic acid signaling in the developing trunk of the embryo from which the limb buds emerge. [ 2 ] [ 3 ] Also, although excess retinoic acid can alter limb patterning by ectopically activating Shh or Meis1/Meis2 expression, genetic studies in mouse that eliminate retinoic ...
Retinoic acid (simplified nomenclature for all-trans-retinoic acid) is a metabolite of vitamin A 1 (all-trans-retinol) that is required for embryonic development, male fertility, regulation of bone growth and immune function. [2] All-trans-retinoic acid is required for chordate animal development, which includes all higher animals from fish to ...
The hindbrain, for example, is patterned by Hox genes, which are expressed in overlapping domains along the anteroposterior axis under the control of retinoic acid. The 3 ′ (3 prime end) genes in the Hox cluster are induced by retinoic acid in the hindbrain, whereas the 5 ′ (5 prime end) Hox genes are not induced by retinoic acid and are ...
CRABPs, cellular retinoic acid–binding proteins capable of binding retinol and retinoic acid with high affinity. [ 15 ] [ 16 ] [ 17 ] It has also been characterized that CRABPs are involved in many aspects of the retinoic acid signaling pathway such as the regulation and availability of retinoic acid to nuclear receptors.
The PAX6 gene locus is a transcription factor for the various genes and growth factors involved in eye formation. [1] [5] Eye morphogenesis begins with the evagination, or outgrowth, of the optic grooves or sulci. These two grooves in the neural folds transform into optic vesicles with the closure of the neural tube. [6]
19662 Ensembl ENSG00000138207 ENSMUSG00000024990 UniProt P02753 Q00724 RefSeq (mRNA) NM_006744 NM_001323517 NM_001323518 NM_001159487 NM_011255 RefSeq (protein) NP_001310446 NP_001310447 NP_006735 NP_001152959 NP_035385 Location (UCSC) Chr 10: 93.59 – 93.6 Mb Chr 19: 38.11 – 38.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Retinol binding protein 4, also known as RBP4, is a ...
The search engine that helps you find exactly what you're looking for. Find the most relevant information, video, images, and answers from all across the Web.
Retinoic acid receptor-alpha, the protein, interacts with retinoic acid, a derivative of vitamin A, which plays an important role in cell growth, differentiation, and the formation of organs in embryonic development. [8] [10] Once retinoic acid binds to the RAR, the heterodimer initiates transcription and allows for its target genes to be ...