Ad
related to: pyrimidine glycosylate and cancer therapy journal articles
Search results
Results From The WOW.Com Content Network
Changes in O-glycosylation are extremely common in cancer. O-glycan structures, and especially the terminal Lewis epitopes, are important in allowing tumor cells to invade new tissues during metastasis. [6] Understanding these changes in O-glycosylation of cancer cells can lead to new diagnostic approaches and therapeutic opportunities. [1]
There are two main classes of glycosylases: monofunctional and bifunctional. Monofunctional glycosylases have only glycosylase activity, whereas bifunctional glycosylases also possess AP lyase activity that permits them to cut the phosphodiester bond of DNA, creating a single-strand break without the need for an AP endonuclease.
For instance, some proteins do not fold correctly unless they are glycosylated. [2] In other cases, proteins are not stable unless they contain oligosaccharides linked at the amide nitrogen of certain asparagine residues. The influence of glycosylation on the folding and stability of glycoprotein is twofold. Firstly, the highly soluble glycans ...
RNA is composed of pyrimidine and purine nucleotides, both of which are necessary for reliable information transfer, and thus natural selection and Darwinian evolution. Becker et al. showed how pyrimidine nucleosides can be synthesized from small molecules and ribose , driven solely by wet-dry cycles.
pyrimidine analogues – mimic the structure of metabolic pyrimidines, the smaller bases incorporated into DNA as cytosine and thymine. Examples: 5-Fluorouracil, Gemcitabine, and Cytarabine; nucleoside analogues – nucleoside alternatives that consist of a nucleic acid analogue and a sugar. This means these are the same bases as above, but ...
This energy pathway is upregulated in cancer, which may represent a therapeutic target as cancer cells are thought to be more dependent on glutamine than healthy cells. [24] This especially holds true for specific tumor types that are metabolically dysregulated, such as malignant brain tumors (i.e. glioblastoma ) that carry mutations in the ...
Clinical Cancer Research is a peer-reviewed medical journal on oncology, including the cellular and molecular characterization, prevention, diagnosis, and therapy of human cancer, medical and hematological oncology, radiation therapy, pediatric oncology, pathology, surgical oncology, and clinical genetics.
Over activation of the PI3K pathway is frequently present in human malignancies and plays a key role in cancer progression. [5] Due to the multiple sub-cellular locations, activities, and importance of the different PI3K isoforms and complexes in regulating cancer cell proliferation, complete control of the PI3K pathway activity is an important ...