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  2. Primary transcript - Wikipedia

    en.wikipedia.org/wiki/Primary_transcript

    Transcription produces primary transcripts that are further modified by several processes. These processes include the 5' cap, 3'-polyadenylation, and alternative splicing. In particular, alternative splicing directly contributes to the diversity of mRNA found in cells. The modifications of primary transcripts have been further studied in ...

  3. Transcription (biology) - Wikipedia

    en.wikipedia.org/wiki/Transcription_(biology)

    During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, antiparallel RNA strand called a primary transcript. In virology , the term transcription is used when referring to mRNA synthesis from a viral RNA molecule.

  4. Eukaryotic transcription - Wikipedia

    en.wikipedia.org/wiki/Eukaryotic_transcription

    Termination of transcription occurs in the ribosomal intergenic spacer region that contains several transcription termination sites upstream of a Pol I pausing site. Through a yet unknown mechanism, the 3’-end of the transcript is cleaved, generating a large primary rRNA molecule that is further processed into the mature 18S, 5.8S and 28S rRNAs.

  5. Central dogma of molecular biology - Wikipedia

    en.wikipedia.org/wiki/Central_dogma_of_molecular...

    Transcription is the process by which the information contained in a section of DNA is replicated in the form of a newly assembled piece of messenger RNA (mRNA). Enzymes facilitating the process include RNA polymerase and transcription factors. In eukaryotic cells the primary transcript is pre-mRNA. Pre-mRNA must be processed for translation to ...

  6. Post-transcriptional modification - Wikipedia

    en.wikipedia.org/wiki/Post-transcriptional...

    Transcriptional modification or co-transcriptional modification is a set of biological processes common to most eukaryotic cells by which an RNA primary transcript is chemically altered following transcription from a gene to produce a mature, functional RNA molecule that can then leave the nucleus and perform any of a variety of different functions in the cell. [1]

  7. Transcriptional regulation - Wikipedia

    en.wikipedia.org/wiki/Transcriptional_regulation

    Several cell function specific transcription factor proteins (in 2018 Lambert et al. indicated there were about 1,600 transcription factors in a human cell [41]) generally bind to specific motifs on an enhancer [22] and a small combination of these enhancer-bound transcription factors, when brought close to a promoter by a DNA loop, govern the ...

  8. Transcription factor - Wikipedia

    en.wikipedia.org/wiki/Transcription_factor

    Upstream transcription factors are proteins that bind somewhere upstream of the initiation site to stimulate or repress transcription. These are roughly synonymous with specific transcription factors , because they vary considerably depending on what recognition sequences are present in the proximity of the gene.

  9. Transcription factory - Wikipedia

    en.wikipedia.org/wiki/Transcription_factory

    Transcription is made more efficient because of the clustered nature of the transcription factory. All the necessary proteins: RNA polymerase, transcription factors and other co-regulators are present in the transcription factory that allows for faster RNA polymerisation when the DNA template reaches the factory, it also allows for a number of ...