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Elevated alkaline phosphatase occurs when levels of alkaline phosphatase (ALP) exceed the reference range. This group of enzymes has a low substrate specificity and catalyzes the hydrolysis of phosphate esters in a basic environment. The major function of alkaline phosphatase is transporting chemicals across cell membranes. [1]
The enzyme alkaline phosphatase (ALP, alkaline phenyl phosphatase) is a phosphatase with the physiological role of dephosphorylating compounds. The enzyme is found across a multitude of organisms, prokaryotes and eukaryotes alike, with the same general function, but in different structural forms suitable to the environment they function in. Alkaline phosphatase is found in the periplasmic ...
Alkaline phosphatase (ALP) is an enzyme in the cells lining the biliary ducts of the liver. It can also be found on the mucosal epithelium of the small intestine, proximal convoluted tubule of the kidneys, bone, liver, and placenta. It plays an important role in lipid transposition in small intestines and calcification of bones. 50% of all the ...
References range may vary with age, sex, race, pregnancy, [10] diet, use of prescribed or herbal drugs and stress. Reference ranges often depend on the analytical method used, for reasons such as inaccuracy, lack of standardisation, lack of certified reference material and differing antibody reactivity. [11]
The Alps continue fairly smoothly into the following related Alpine mountain ranges: the Apennines to the southwest, the Dinarides to the southeast and the Carpathians to the northeast. In the east the Alps are bounded by the Viennese Basin and the Pannonian Basin, where east–west stretching of the crust takes place.
The severity of symptoms ranges from premature loss of deciduous teeth with no bone abnormalities to stillbirth [18] depending upon which amino acid [19] [20] is changed in the ALPL gene. Mutations in the ALPL gene lead to varying low activity of the enzyme tissue-nonspecific alkaline phosphatase (TNSALP or TNAP) resulting in hypophosphatasia ...
Gen Z was born between 1997 and 2012 and is considered the first generation to have largely grown up using the internet, modern technology and social media.
The mean precipitation in the Alps ranges from a low of 2,600 mm (100 in) per year to 3,600 mm (140 in) per year, with the higher levels occurring at high altitudes. At altitudes between 1,000 and 3,000 m (3,300 and 9,800 ft), snowfall begins in November and accumulates through to April or May when the melt begins.
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