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Mucous cells of the stomach lining secrete mucus (pink) into the lumen. Mucus (/ ˈ m j uː k ə s /, MEW-kəs) is a slippery aqueous secretion produced by, and covering, mucous membranes. It is typically produced from cells found in mucous glands, although it may also originate from mixed glands, which contain both serous and mucous cells.
The mucosa is composed of one or more layers of epithelial cells that secrete mucus, and an underlying lamina propria of loose connective tissue. [1] The type of cells and type of mucus secreted vary from organ to organ and each can differ along a given tract. [2] [3]
Mucous glands, also known as muciparous glands, are found in several different parts of the body, and they typically stain lighter than serous glands during standard histological preparation. Most are multicellular, but goblet cells are single-celled glands.
Foveolar cells or surface mucous cells are mucus-producing cells which cover the inside of the stomach, protecting it from the corrosive nature of gastric acid. [1] [a] These cells line the gastric mucosa and the gastric pits. Mucous neck cells are found in the necks of the gastric glands.
The main role of goblet cells is to secrete mucus in order to protect the mucous membranes where they are found. Goblet cells accomplish this by secreting mucins, large glycoproteins formed mostly by carbohydrates. The gel-like properties of mucins are given by its glycans (bound carbohydrates) attracting relatively large quantities of water. [10]
The sodium-iodide symporter (SIP) is expressed in all the surface mucous cells (at the basolateral membrane) but not in the mucous neck cells. SIP mediates the transport of iodide from the bloodstream and secretes it into the gastric lumen where it is taken up in the gastric juice. Its role is not known but it has been shown to be absent in ...
Mucous neck cells produce mucus, parietal cells secrete hydrochloric acid and intrinsic factor, chief cells secrete pepsinogen and gastric lipase. [ 4 ] The other type of gastric gland is the pyloric gland which is an endocrine gland that secretes the hormone gastrin produced by its G cells .
Goblet cells, so named because they are shaped like a wine goblet, are columnar epithelial cells that contain membrane-bound mucous granules and secrete mucus as part of the airway surface liquid (ASL), also known as the epithelial lining fluid, the composition of which is tightly regulated; the mucus helps maintain epithelial moisture and ...