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The term usually refers to damage induced by excessive use of combinations of these medications, especially combinations that include phenacetin. It may also be used to describe kidney injury from any single analgesic medication. The specific kidney injuries induced by analgesics are renal papillary necrosis and chronic interstitial nephritis.
There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity. Nephrotoxicity should not be confused with some medications predominantly excreted by the kidneys needing their dose adjusted for the decreased kidney function (e.g., heparin, lithium).
Hypermagnesemia can greatly increase the chances of adverse cardiovascular events. [1] [3] Complications may include low blood pressure and cardiac arrest. [1] [5] It is typically caused by kidney failure or is treatment-induced such as from antacids or supplements that contain magnesium.
Kidney disease results from kidney damage and subsequent decline in kidney function. ... "Without treatment, chronic kidney disease can lead to end-stage kidney failure, which is fatal without ...
Experimental studies in animals have shown that PDE5 inhibitors may reverse kidney damage independently of their effects on blood pressure through intra-renal mechanisms. [3] In humans, PDE5 inhibitors have also been shown to reduce proteinuria, a marker of kidney damage. [3]
Additional complications may include kidney failure, pancreatitis, low blood sugar, and lactic acidosis. If death does not occur, people tend to recover fully over a couple of weeks. [3] [4] Without treatment, death from toxicity occurs 4 to 18 days later. [5] Paracetamol poisoning can occur accidentally or as an attempt to die by suicide.
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