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In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance ...
Reaction calorimetry may be classified as a differential technique since the primary data collected are proportional to rate vs. time. From these data, the starting material or product concentration over time may be obtained by simply taking the integral of a polynomial fit to the experimental curve.
In pharmacology, in order to determine absolute bioavailability of a drug, a pharmacokinetic study must be done to obtain a plasma drug concentration vs time plot for the drug after both intravenous (iv) and extravascular (non-intravenous, i.e., oral) administration.
That is, the closer time points are, the closer the trapezoids reflect the actual shape of the concentration-time curve. The number of time points available in order to perform a successful NCA analysis should be enough to cover the absorption, distribution and elimination phase to accurately characterize the drug.
The plot of against has often been called a "Michaelis–Menten plot", even recently, [7] [8] [9] but this is misleading, because Michaelis and Menten did not use such a plot. Instead, they plotted v {\displaystyle v} against log a {\displaystyle \log a} , which has some advantages over the usual ways of plotting Michaelis–Menten data.
It is a semi-log plot with acetaminophen levels (on a logarithmic scale) along the vertical axis versus time (on a linear scale) along the horizontal axis. Rumack–Matthew Nomogram showing acetaminophen level versus time as a method of interpreting levels and assessing severity and need for treatment.
A plot depicting the specific growth rate versus substrate concentration as modeled by the Monod equation (solid line) and the Haldane equation for substrate inhibition (dotted line). Under single-substrate inhibiting conditions, the Monod equation is no longer suitable, and the most common Monod derivative is once again in the form of the ...
This plot of sample concentration versus time is called a chromatogram. The ultimate goal of chromatography is to separate different components from a solution mixture. The resolution expresses the extent of separation between the components from the mixture.