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A depot injection, also known as a long-acting injectable (LAI), is a term for an injection formulation of a medication which releases slowly over time to permit less frequent administration of a medication.
Depo-Provera is the brand name for a 150 mg microcrystalline aqueous suspension of DMPA that is administered by intramuscular injection. The shot must be injected into thigh, buttock, or deltoid muscle four times a year (every 11 to 13 weeks), and provides pregnancy protection instantaneously after the first injection. [ 68 ]
[3]: 722 For subcutaneous injections delivered using devices such as injector pens, the needle used may be as thin as 34 gauge (commonly 30–32 gauge), and as short as 3.5 mm (commonly 3.5 mm to 5 mm). [24] Subcutaneous injections can also be delivered via a pump system which uses a cannula inserted under the skin.
This device is known as a disposable-cartridge jet injector (DCJI). [2] The International Standards Organization recommended abandoning the use of the name "jet injector", which is associated with a risk of cross-contamination and rather refer to newer devices as "needle-free injectors". [4]
Today, pen needles are manufactured at shorter needle lengths than required for typical vial and syringe administration, which decreases the pain associated with injection. [2] They are available in multiple lengths and gauge of needle , including 3.5mm, 4mm, 5mm, and 8mm lengths, and 31 through 34 gauge. [ 8 ]
[60] [93] For comparison, the dose of medroxyprogesterone acetate (MPA; 6α-methyl-17α-hydroxyprogesterone acetate), a close analogue of hydroxyprogesterone caproate, used by intramuscular injection in microcrystalline aqueous suspension in once-a-month combined injectable contraceptives, is 25 mg. [60] [81] It has also been said that given by ...