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Radiation-induced lung injury (RILI) is a general term for damage to the lungs as a result of exposure to ionizing radiation. [1] In general terms, such damage is divided into early inflammatory damage ( radiation pneumonitis ) and later complications of chronic scarring ( radiation fibrosis ).
Side effects on the lungs can be very varied, and can include signs and symptoms that are either clinical, or radiological (i.e., seen on chest X-ray or CT), or both.They can include lung inflammation (pneumonitis), secondary (in this context, indirectly caused) lung infection (), lung fibrosis, organising pneumonia (bronchiolitis obliterans organising pneumonia, BOOP), ARDS (acute respiratory ...
Radiation, used to treat cancer, can cause pneumonitis when applied to the chest or full body. [16] Radiation pneumonitis occurs in approximately 30% of advanced lung cancer patients treated with radiation therapy. [16] Aspiration pneumonitis is caused by a chemical inhalation of harmful gastric contents which include causes such as:
The lungs are the most radiosensitive organ, and radiation pneumonitis can occur leading to pulmonary insufficiency and death (100% after exposure to 50 Gray of radiation), in a few months. Radiation pneumonitis is characterized by: [10] Loss of epithelial cells; Edema; Inflammation; Occlusions of airways, air sacs and blood vessels; Fibrosis
Acute radiation syndrome (ARS), also known as radiation sickness or radiation poisoning, is a collection of health effects that are caused by being exposed to high amounts of ionizing radiation in a short period of time. [1] Symptoms can start within an hour of exposure, and can last for several months.
Radiation-induced lung injury (RILI) encompasses radiation pneumonitis and pulmonary fibrosis. Lung tissue is sensitive to ionizing radiation, tolerating only 18–20 Gy, [41] a fraction of typical therapeutic dosage levels. The lung's terminal airways and associated alveoli can become damaged, preventing effective respiratory gas exchange.
Pneumonitis refers to lung inflammation; pneumonia refers to pneumonitis, usually due to infection but sometimes non-infectious, that has the additional feature of pulmonary consolidation. [81] Pneumonia is most commonly classified by where or how it was acquired: community-acquired, aspiration, healthcare-associated , hospital-acquired , and ...
Stereotactic External-Beam radiation Therapy, sometimes called SBRT is now being used to treat Small Cell Lung Cancer, and Sarcomas that have metastasized to the lungs. The high doses used in thoracic SBRT can sometimes cause adverse effects ranging from mild rib fatigue and transient esophagitis , to fatal events such as pneumonitis or hemorrhage.