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Cutaneous squamous-cell carcinoma is the second-most common cancer of the skin (after basal-cell carcinoma, but more common than melanoma). It usually occurs in areas exposed to the sun. Sunlight exposure and immunosuppression are risk factors for SCC of the skin, with chronic sun exposure being the strongest environmental risk factor. [26]
UV light is known to damage skin cells by mutating their DNA. The mutated DNA can cause tumors and other growths to form on the skin. Further, there are other risk factors beside just UV exposure. Fair skin, prolonged history of sunburns, moles, and family history of skin cancer are just a few. [52]
Conditions of or affecting the human integumentary system associated with increased risk of nonmelanoma skin cancer Condition Squamous-cell carcinoma Basal-cell carcinoma; Xeroderma pigmentosum + + Oculocutaneous albinism + + Epidermodysplasia verruciformis + Recessive dystrophic epidermolysis bullosa + Ferguson–Smith syndrome + Muir–Torre ...
The Fitzpatrick scale has been criticized for its Eurocentric bias and insufficient representation of global skin color diversity. [9] The scale originally was developed for classifying "white skin" in response to solar radiation, [2] and initially included only four categories focused on white skin, with "brown" and "black" skin types (V and VI) added as an afterthought.
This template is designed to be used in a table to make a cell with text in that cell, with an appropriately colored background. It can be used in comparison tables with descriptions of risk, hazard, criticality, threat or severity level. There are many risk assessment systems using a varying number of risk categories.
In the United States, excess body weight is associated with the development of many types of cancer and is a factor in 14–20% of all cancer deaths. [34] Every year, nearly 85,000 new cancer diagnoses in the United States are related to obesity. [54]
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The most deadly form of skin cancer, malignant melanoma, is mostly caused by DNA damage independent from UVA radiation. This can be seen from the absence of a direct UV signature mutation in 92% of all melanoma. [66] Occasional overexposure and sunburn are probably greater risk factors for melanoma than long-term moderate exposure. [67]