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Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. [ 5 ] [ 6 ] CTCF is involved in many cellular processes, including transcriptional regulation , insulator activity, V(D)J recombination [ 7 ] and regulation of chromatin architecture.
Topologically associating domains within chromosome territories, their borders and interactions. A topologically associating domain (TAD) is a self-interacting genomic region, meaning that DNA sequences within a TAD physically interact with each other more frequently than with sequences outside the TAD. [1]
^ ASN.1 has X.681 (Information Object System), X.682 (Constraints), and X.683 (Parameterization) that allow for the precise specification of open types where the types of values can be identified by integers, by OIDs, etc. OIDs are a standard format for globally unique identifiers, as well as a standard notation ("absolute reference") for ...
CTCF molecules can form homodimers on DNA, which can be co-bound by cohesin; this chromatin loop structure helps constrain the ability of enhancers within the loop to target genes outside the loop. Loops with CTCF and cohesin at the start and end of the loop that restrict enhancer-gene targeting are "insulated neighborhoods."
Moreover, CTCF and cohesin play important roles in determining TADs and enhancer-promoter interactions. The result shows that the orientation of CTCF binding motifs in an enhancer-promoter loop should be facing to each other in order for the enhancer to find its correct target.
CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. Transcriptional repressor CTCFL (this protein) is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and CTCFL are normally expressed in a ...
The GDF format is often used in brain–computer interface research. [4] [5] [6] However, since GDF provides a superset of features from many different file formats, it could be also used for many other domains. The free and open source software BioSig library provides implementations for reading and writing of GDF in GNU Octave/MATLAB and C ...
Thus, the loop can become smaller or larger. The loop extrusion process stops when cohesin encounters the architectural chromatin protein CTCF. The CTCF site needs to be in a proper orientation to stop cohesin. [31] [32] [33] Accumulation at promoters: Two hypotheses were proposed to explain accumulation of cohesin at the gene promoters: [34] [35]