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  2. Telomerase reverse transcriptase - Wikipedia

    en.wikipedia.org/wiki/Telomerase_reverse...

    [17] iPS cells derived from DKC patients with a heterozygous mutation on the TERT gene display a 50% reduction in telomerase activity compared to wild type iPS cells. [38] Conversely, mutations on the TERC gene (RNA portion of telomerase complex) can be overcome by up-regulation due to reprogramming as long as the hTERT gene is intact and ...

  3. Telomerase - Wikipedia

    en.wikipedia.org/wiki/Telomerase

    The genes of telomerase subunits, which include TERT, [16] TERC, [17] DKC1 [18] and TEP1, [19] are located on different chromosomes. The human TERT gene (hTERT) is translated into a protein of 1132 amino acids. [20] TERT polypeptide folds with (and carries) TERC, a non-coding RNA (451 nucleotides long). TERT has a 'mitten' structure that allows ...

  4. Telomerase RNA component - Wikipedia

    en.wikipedia.org/wiki/Telomerase_RNA_component

    The core domain of TERC contains the RNA template from which TERT synthesizes TTAGGG telomeric repeats. [10] Unlike in other RNPs, in telomerase, the protein TERT is catalytic while the lncRNA TERC is structural, rather than acting as a ribozyme. [14] The core region of TERC and TERT are sufficient to reconstitute catalytic telomerase activity ...

  5. Plant genetics - Wikipedia

    en.wikipedia.org/wiki/Plant_genetics

    An image of multiple chromosomes, taken from many cells. Plant genetics is the study of genes, genetic variation, and heredity specifically in plants. [1] [2] It is generally considered a field of biology and botany, but intersects frequently with many other life sciences and is strongly linked with the study of information systems.

  6. ABC model of flower development - Wikipedia

    en.wikipedia.org/wiki/ABC_model_of_flower...

    The fact that these homeotic genes determine an organ's identity becomes evident when a gene that represents a particular function, for example the A gene, is not expressed. In Arabidopsis this loss results in a flower which is composed of one verticil of carpels, another containing stamens and another of carpels. [10]

  7. Autonomously replicating sequence - Wikipedia

    en.wikipedia.org/wiki/Autonomously_replicating...

    The A-Domain is highly conserved, any mutation abolishes origin function. Mutations on B1, B2, and B3 will diminish, but not prevent functioning of the origin. Element A is highly conserved, consisting of the consensus sequence: 5'- T/A T T T A Y R T T T T/A -3' (where Y is either pyrimidine and R is either purine). When this element is mutated ...

  8. Genetic engineering techniques - Wikipedia

    en.wikipedia.org/wiki/Genetic_engineering_techniques

    The gene must then be isolated and incorporated, along with other genetic elements, into a suitable vector. This vector is then used to insert the gene into the host genome, creating a transgenic or edited organism. The ability to genetically engineer organisms is built on years of research and discovery on gene function and manipulation.

  9. Telomeric repeat-binding factor 2 - Wikipedia

    en.wikipedia.org/wiki/Telomeric_repeat-binding...

    Also, TERF2 has a basic N-terminus, differing from TERF1’s acidic N-terminus, and was found to be much more conserved, suggesting that the two proteins have distinct functions. [ 7 ] There are 4 domain categories on the TERF2 protein that allow it to bind to both other proteins in the shelterin protein complex, and to specific types of DNA.