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An autoimmune response to Type II collagen, which is found in cartilage and the sclera of the eye, may play a role in the pathophysiology of RP. [5] A genetic connection to HLA-DR4 (DRB1*04 subtype alleles) may also exist. [5] About 30% of cases of RP are linked to additional illnesses, such as autoimmune disorders. [5]
IFN-gamma is an antifibrotic cytokine which alters collagen synthesis and helps in OSF. [30] Colchicine tablets 0.5 mg twice a day [31] Lycopene, 16 mg a day helps in improvement of OSF [32] The treatment of patients with oral submucous fibrosis depends on the degree of clinical involvement. [33]
Collagens are complex molecules that provide structure, strength, and elasticity to connective tissue. Type II and type XI collagen disorders are grouped together because both types of collagen are components of the cartilage found in joints and the spinal column, the inner ear, and the jelly-like substance that fills the eyeball (the vitreous ...
MCTD has no specific treatment. Management should address the individual's primary issues, such as arthritis, skin disease, or visceral involvement. Low-dose glucocorticoids, nonsteroidal anti-inflammatory medications, hydroxychloroquine, or a combination of these therapies can effectively treat many patients. [65]
dry eyes, dry mouth, hair loss, joint inflammation, joint pain, mouth ulcers, positive ANA test, raynaud's phenomenon, sun-sensitive rash... Undifferentiated connective tissue disease ( UCTD ) (also known as latent lupus or incomplete lupus [ 1 ] ) is a disease in which the connective tissues are targeted by the immune system.
Type 1 Diabetes: Autoimmune Disease. ... dry mouth, fatigue, ... or treatment. Talk with your doctor before starting any new medicine, supplement, weight loss or exercise regimen. ...
The mouth may act as a reservoir of Candida that reinfects the sores at the corners of the mouth and prevents the sores from healing. [citation needed] A lesion caused by recurrence of a latent herpes simplex infection can occur in the corner of the mouth. This is herpes labialis (a cold sore), and is sometimes termed "angular herpes simplex". [2]
Collagen disease is a term previously used to describe systemic autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis), but now is thought to be more appropriate for diseases associated with defects in collagen, which is a component of the connective tissue.