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A foreign-body giant cell is a collection of fused macrophages which are generated in response to the presence of a large foreign body. This is particularly evident with catheters , parasites , or biomaterials that are inserted into the body for replacement or regeneration of diseased or damaged tissues.
A giant cell (also known as a multinucleated giant cell, or multinucleate giant cell) is a mass formed by the union of several distinct cells (usually histiocytes), often forming a granuloma. [ 1 ] Although there is typically a focus on the pathological aspects of multinucleate giant cells (MGCs), they also play many important physiological roles.
Intake of drugs that depress neurologic function may also lead to aspiration. The resultant granulomas are typically found around the airways (bronchioles), and are often accompanied by foreign body-type, multinucleated giant cells, acute inflammation, or organizing pneumonia. The finding of food particles in lung biopsies is diagnostic. [17]
Foreign body granuloma formation consists of protein adsorption, macrophages, multinucleated foreign body giant cells (macrophage fusion), fibroblasts, and angiogenesis. It has also been proposed that the mechanical property of the interface between an implant and its surrounding tissues is critical for the host response.
Granulation tissue with a poorly formed granuloma to the left of centre. Within this area there is a multinucleate giant cell of the Langhans type. The patient had a healing mycobacterial infection of the skin (Mycobacterium ulcerans infection). Langhans giant cells (LGC) are giant cells found in granulomatous conditions.
Touton giant cells, being multinucleated giant cells, can be distinguished by the presence of several nuclei in a distinct pattern. This pattern is described as a ring-like or wreath-like in the center of a cell. These cells contain a ring of nuclei surrounding a central homogeneous cytoplasm, while foamy cytoplasm surrounds the nuclei.
High magnification photomicrograph of a lung biopsy taken showing chronic hypersensitivity pneumonitis , showing mild thickening of the walls of the small air sacs by invasion of white blood cells. A multinucleated giant cell, seen within the walls of the air sacs to the right of the picture halfway down, is an important clue to the correct ...
Epithelioid cell granuloma can be defined as specifically and structurally organized collection of epithelioid cells, macrophages, lymphocytes and dendritic cells. Foreign-body granulomas may be considered an organized collection of macrophages, including mere collections of giant cells surrounding inert substances like suture material – the ...