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Approximately 98% of lung cancers are carcinoma, a term describing malignancies derived from transformed cells exhibiting characteristics of epithelium. About 2% of all lung cancers are non-carcinoma (mainly sarcoma, tumors of hematopoietic origin, or germ cell tumors. [5] These forms of lung cancer are usually treated differently from carcinomas.
Scientist Otto Warburg, whose research activities led to the formulation of the Warburg hypothesis for explaining the root cause of cancer.. The Warburg hypothesis (/ ˈ v ɑːr b ʊər ɡ /), sometimes known as the Warburg theory of cancer, postulates that the driver of carcinogenesis (cancer formation) is insufficient cellular respiration caused by insult (damage) to mitochondria. [1]
Lung cancer is the most diagnosed and deadliest cancer worldwide, with 2.2 million cases in 2020 resulting in 1.8 million deaths. [3] Lung cancer is rare in those younger than 40; the average age at diagnosis is 70 years, and the average age at death 72. [2] Incidence and outcomes vary widely across the world, depending on patterns of tobacco use.
ME (minimum evolution), Kidd and Sgaramella-Zonta [55] (it is unclear if this is the pairwise distance method or related to ML as Edwards and Cavalli-Sforza call ML "minimum evolution"). 1972, Adams consensus, Adams. [56] 1976, prefix system for ranks, Farris. [57] 1977, Dollo parsimony, Farris. [58] 1979 Nelson consensus, Nelson. [59]
Lung Cancer is a peer-reviewed medical journal published by Elsevier originally published on behalf of the International Association for the Study of Lung Cancer (until 2006). As of 2015, it is published on behalf of the International Lung Cancer Consortium , the European Thoracic Oncology Platform , and the British Thoracic Oncology Group . [ 1 ]
Basaloid forms of lung carcinoma were first described in the peer-reviewed medical literature by Dr. Elisabeth Brambilla and her colleagues in 1992. [11] They were first recognized as distinct clinicopathological variants of both squamous cell and large cell lung cancers in 1999, within the third revision of the World Health Organization lung tumor typing and classification scheme.