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Tocilizumab, sold under the brand name Actemra among others, is an immunosuppressive drug, used for the treatment of rheumatoid arthritis, systemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, giant cell arteritis, cytokine release syndrome, COVID‑19, and systemic sclerosis-associated interstitial lung disease (SSc-ILD).
During the COVID-19 pandemic, antagonistic antibodies against the IL-6 receptors were tested in clinical trials to assess their use in treating or preventing severe pneumonia in critically ill COVID-19 patients. Such antibodies include tocilizumab and sarilumab. [18] [19] [20] Antibodies against IL-6 itself, such as siltuximab, were also ...
Interleukin 6 (IL-6) is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma and prostate cancer. Tocilizumab was jointly developed by Osaka University and Chugai, and was licensed in 2003 by Hoffmann-La Roche. [24]
The CHMP recommends EU approval for Roche's (RHHBY) Actemra to treat patients with severe COVID-19.
Of the 204 participants who were infected with the coronavirus but were symptom-free when they entered the study, the antibody injection reduced their risk of developing Covid symptoms by 32 ...
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene. [5] In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine.
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COVID-19: Cirmtuzumab [32] humanized: ROR1: chronic lymphocytic leukemia Citatuzumab bogatox [49] Fab: humanized: EpCAM: ovarian cancer and other solid tumors Cixutumumab [32] mab: human: IGF-1 receptor (CD221) solid tumors Clazakizumab [50] mab: humanized: IL-6: rheumatoid arthritis: Clenoliximab [32] mab: chimeric: CD4: rheumatoid arthritis ...