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Flucytosine, also known as 5-fluorocytosine (5-FC), is an antifungal medication. [2] It is specifically used, together with amphotericin B, for serious Candida infections and cryptococcosis. [2] It may be used by itself or with other antifungals for chromomycosis. [2] Flucytosine is used by mouth and by injection into a vein. [2] [3]
Intravenous Amphotericin B combined with flucytosine by mouth is recommended for initial treatment (induction therapy). [43] People living with AIDS often have a greater burden of disease and higher mortality (30–70% at 10 weeks), recommended therapy is with amphotericin B and flucytosine.
It was recommended in 2000 that cryptococcal meningitis be treated for two weeks with intravenous amphotericin B 0.7–1.0 mg/kg per day and oral flucytosine 100 mg/kg per day (or intravenous flucytosine 75 mg/kg per day [citation needed] day if the patient is unable to swallow), followed by oral fluconazole 400–800 mg daily for ten weeks [3 ...
Flucytosine (also known as 5-fluorocytosine, 5-FC, and Toca FC) is an antifungal drug. It is used in an extended-release formulation. Flucytosine is a prodrug of 5-fluorouracil (5-FU), a cancer drug. 5-Fluorouracil does not cross the blood–brain barrier well, but flucytosine does. [1]
Hand, foot and mouth disease (HFMD) A diagnosis usually can be made by the presenting signs and symptoms alone. If the diagnosis is unclear, a throat swab or stool specimen may be taken. Medications are usually not needed as hand, foot, and mouth disease is a viral disease that typically resolves on its own. Under research [15] [16] Sin Nombre ...
Oral administration is a route of administration whereby a substance is taken through the mouth, swallowed, and then processed via the digestive system. This is a common route of administration for many medications. Oral administration can be easier and less painful than other routes of administration, such as injection.
Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis. [3] The fungal infections it is used to treat include mucormycosis, aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, and cryptococcosis. [4]
It is given either by mouth or by injection into a vein. [5] Common side effects include vomiting, diarrhea, rash, and increased liver enzymes. [5] Serious side effects may include liver problems, QT prolongation, and seizures. [5] During pregnancy it may increase the risk of miscarriage while large doses may cause birth defects.