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Beclometasone or beclomethasone, also known as beclomethasone dipropionate, and sold under the brand name Qvar among others, is a steroid medication. [1] It is available as an inhaler, cream, pills, and nasal spray. [2] The inhaled form is used in the long-term management of asthma. [1] The cream may be used for dermatitis and psoriasis. [3]
Very long duration of action (12–24 hours) Huge improvement in lung function and symptoms; Risk of exacerbation greatly lowered → LAMA more prominent than LABA; Provided in inhalers → techniques for usage is important for management of COPD [31] Caution [28] Should not be used in acute exacerbation for rapid relieve of symptoms
MDI canister and actuator components from H&T Presspart. A metered-dose inhaler consists of three major components: the canister, which is produced in aluminum or stainless steel by means of deep drawing, where the formulation resides; the metering valve, which allows a metered quantity of the formulation to be dispensed with each actuation; and an actuator (or mouthpiece) which enables the ...
Tidal volume increases by 30–40%, from 0.5 to 0.7 litres, [9] and minute ventilation by 30–40% [9] [10] giving an increase in pulmonary ventilation. This is necessary to meet the increased oxygen requirement of the body, which reaches 50 ml/min, 20 ml of which goes to reproductive tissues.
[9] [10] [8] Compared to other marketed OX antagonists, daridorexant has a relatively short elimination half-life of 8 hours and a time to peak of about 1 to 2 hours. [1] [7] [5] It is not a benzodiazepine or Z-drug and does not interact with GABA receptors, instead having a distinct mechanism of action. [8] [7]
Men may have a reduced refractory period and may be capable of multiple orgasms. [16] According to some studies, 18-year-old males have a refractory period of about 15 minutes, while those in their 70s take about 20 hours. [17] Although rarer, some males exhibit no refractory period or a refractory period lasting less than 10 seconds. [18]
Armodafinil exhibits linear time-independent kinetics following single and multiple oral dose administration. Increase in systemic exposure is proportional over the dose range of 50–400 mg. No time-dependent change in kinetics was observed through 12 weeks of dosing. Apparent steady state for armodafinil was reached within 7 days of dosing.
Tirofiban, sold under the brand name Aggrastat, is an antiplatelet medication.It belongs to a class of antiplatelets named glycoprotein IIb/IIIa inhibitors.Tirofiban is a small molecule inhibitor of the protein-protein interaction between fibrinogen and the platelet integrin receptor GP IIb/IIIa and is the first drug candidate whose origins can be traced to a pharmacophore-based virtual ...