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Human lung microvascular endothelial cells (HLMVECs) are cells derived from the pulmonary endothelium. HLMVECs are used as a laboratory model system for the study of the function and pathology of the pulmonary endothelium to research conditions such as ARDS [ 1 ] HLMVECs are used due to their simple techniques for isolating them from adult ...
Human Cell Atlas; Content; Description: The Human Cell Atlas is a global consortium that is creating detailed maps of the cells in the human body to transform understanding of health and disease. Organisms: Human: Contact; Primary citation: Regev, Aviv; et al. (Human Cell Atlas Organizing Committee) (2018). "The Human Cell Atlas White Paper".
Among the products of the program is the Azimuth reference datasets for single-cell RNA seq data [2] [3] and the ASCT+B Reporter, a visualization tool for anatomical structures, cell types and biomarkers. [4] [5] Millitomes are used to create uniformly sized tissue blocks that match the shape and size of organs from HuBMAP's 3D Reference Object ...
The Human Cell Atlas project, which started in 2016, had as one of its goals to "catalog all cell types (for example, immune cells or brain cells) and sub-types in the human body". [13] By 2018, the Human Cell Atlas description based the project on the assumption that "our characterization of the hundreds of types and subtypes of cells in the ...
Schematic drawing of a lung-on-a-chip. The membrane in the middle can be stretched by vacuum in the two side chambers. Lung-on-a-chip (LoC), also known as Lung Chips, are micro- and millifluidic organ-on-a-chip devices designed to replicate the structure and function of the human lung, mimicking the breathing motions and fluid dynamics that occur during inhalation and exhalation. [1]
Precision-cut Lung Slices (PCLS) have been instrumental in studying the body's innate responses to viral and, to a lesser extent, bacterial challenges. This system has shed light on which cells become infected within the intact lung, offering insights distinct from in vitro air-liquid interface cultures. [25]