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Paradoxical laughter has been consistently identified as a recurring emotional-cognitive symptom in schizophrenia diagnosis. Closely linked to paradoxical laughter is the symptom; inappropriate affect, defined by the APA Dictionary of Psychology as "emotional responses that are not in keeping with the situation or are incompatible with expressed thoughts or wishes". [3]
For example, a patient may laugh in response to sad news or cry in response to stimuli with no emotional undertone, or, once provoked, the episodes may switch from laughing to crying or vice versa. [3] The symptoms of PBA can be severe, with persistent and unremitting episodes. [4] Characteristics include:
Inappropriate affect is an emotional expression that does not align with the content of a person's speech or thoughts, or is unsuitable for the situation at hand. [1] This is often observed in individuals with schizophrenia, [2] where emotional responses, such as laughter, may occur in the absence of a relevant stimulus.
'This will turn out to be the most important break in the disease,' the Broad Institute's director Eric Lander said.
The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
Schizophrenia is a mental disorder characterized by significant alterations in perception, thoughts, mood, and behavior. [34] Symptoms are described in terms of positive, negative, and cognitive symptoms. [3] [35] The positive symptoms of schizophrenia are the same for any psychosis and are sometimes referred to as psychotic symptoms. These may ...
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