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Mitochondrial uncoupling protein 3 (UCP3) is a members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and transfer of protons from the outer to the inner mitochondrial membrane, reducing the mitochondrial membrane potential in mammalian cells.
Smale's problems is a list of eighteen unsolved problems in mathematics proposed by Steve Smale in 1998 [1] and republished in 1999. [2] Smale composed this list in reply to a request from Vladimir Arnold, then vice-president of the International Mathematical Union, who asked several mathematicians to propose a list of problems for the 21st century.
A bar model used to solve an addition problem. This pictorial approach is typically used as a problem-solving tool in Singapore math. Singapore math teaches students mathematical concepts in a three-step learning process: concrete, pictorial, and abstract. [3] This learning process was based on the work of an American psychologist, Jerome Bruner.
In Ontario, Canada, where the Ministry of Education has promoted the three-part lesson, the curriculum was changed in the late 1990s in favour of "problem solving based on open-ended investigations rather than memorization". In that province, test scores in grades three and grade six math declined between 2009 and 2013, and "some contend that ...
The Principles and Standards for School Mathematics was developed by the NCTM. The NCTM's stated intent was to improve mathematics education. The contents were based on surveys of existing curriculum materials, curricula and policies from many countries, educational research publications, and government agencies such as the U.S. National Science Foundation. [3]
Thus, on the official website of the Clay Mathematics Institute, these seven problems are officially called the Millennium Problems. To date, the only Millennium Prize problem to have been solved is the Poincaré conjecture. The Clay Institute awarded the monetary prize to Russian mathematician Grigori Perelman in 2010.
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