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Receptor activator of nuclear factor κ B (RANK), also known as TRANCE receptor or TNFRSF11A, is a member of the tumor necrosis factor receptor (TNFR) molecular sub-family. RANK is the receptor for RANK-Ligand and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It is associated with bone ...
Chemical structure of Pexidartinib (PLX3397), an FDA-approved small molecule inhibitor of CSF1R. Structure of monoclonal antibody Emactuzumab light and heavy chain complexed with CSF1R. Because TAM CSF1R signaling is tumor-permissive and can cause tumor treatment-resistance, CSF1R signaling is a promising therapeutic target in the treatment of ...
8600 21943 Ensembl ENSG00000120659 ENSMUSG00000022015 UniProt O14788 O35235 RefSeq (mRNA) NM_003701 NM_033012 NM_011613 RefSeq (protein) NP_003692 NP_143026 NP_035743 Location (UCSC) Chr 13: 42.56 – 42.61 Mb Chr 14: 78.51 – 78.55 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Receptor activator of nuclear factor kappa- Β ligand (RANKL), also known as tumor necrosis factor ...
The disequilibrium caused by these changes often causes withdrawal when the long-term use of a drug is discontinued. Upregulation and downregulation can also happen as a response to toxins or hormones. An example of upregulation in pregnancy is hormones that cause cells in the uterus to become more sensitive to oxytocin.
RANKL is a member of the TNF superfamily of ligands. Through binding to the RANK receptor it activates various molecules, like NF-kappa B, MAPK, NFAT and PI3K52. The RANKL/RANK signaling pathway regulates osteoclastogenesis, as well as, the survival and activation of osteoclasts. [56] [57]
Trace amine-associated receptor 1 (TAAR1) is a trace amine-associated receptor (TAAR) protein that in humans is encoded by the TAAR1 gene. [5]TAAR1 is a primarily intracellular amine-activated G s-coupled and G q-coupled G protein-coupled receptor (GPCR) that is primarily expressed in several peripheral organs and cells (e.g., the stomach, small intestine, duodenum, and white blood cells ...
Signal sampling representation. The continuous signal S(t) is represented with a green colored line while the discrete samples are indicated by the blue vertical lines. In signal processing, sampling is the reduction of a continuous-time signal to a discrete-time signal. A common example is the conversion of a sound wave to a sequence of "samples".
EETs have the opposite effects. They are one type of endothelium-derived hyperpolarizing factor, i.e. a substance and/or electrical signal synthesized or generated in and released from the vascular endothelium that hyperpolarize nearby vascular smooth muscle cells. This causes these cells to relax and thereby lowers blood pressure.