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T 3 and T 4 are partially composed of iodine, derived from food. [2] A deficiency of iodine leads to decreased production of T 3 and T 4, enlarges the thyroid tissue and will cause the disease known as simple goitre. [3] The major form of thyroid hormone in the blood is thyroxine (T 4), whose half-life of around one week [4] is longer than that ...
Levothyroxine, also known as L-thyroxine, is a synthetic form of the thyroid hormone thyroxine (T 4). [5] [8] It is used to treat thyroid hormone deficiency (hypothyroidism), including a severe form known as myxedema coma. [5]
It is the primary form of thyroid hormone found in the blood and acts as a prohormone of the more active thyroid hormone, triiodothyronine (T 3). [1] Thyroxine and its active metabolites are essential for regulating metabolic rate, supporting heart and muscle function, promoting brain development, and maintaining bone health. [2] [3]
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T 3 and T 4 are released into the blood. The hormones secreted from the gland are about 80–90% T 4 and about 10–20% T 3. [36] [37] Deiodinase enzymes in peripheral tissues remove the iodine from MIT and DIT and convert T 4 to T 3 and RT 3. [34] This is a major source of both RT 3 (95%) and T 3 (87%) in peripheral tissues. [38]