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The 2021 European Society of Cardiology guidelines for the diagnosis and treatment of acute and chronic heart failure subdivided heart failure into three categories on the basis of LVEF: [21] normal or preserved LVEF [≥50%] (HFpEF) moderately reduced LVEF [in the range of 41–49%] (HFmrEF) reduced LVEF [≤40%] (HFrEF)]
Heart failure with preserved ejection fraction (HFpEF) is a form of heart failure in which the ejection fraction – the percentage of the volume of blood ejected from the left ventricle with each heartbeat divided by the volume of blood when the left ventricle is maximally filled – is normal, defined as greater than 50%; [1] this may be measured by echocardiography or cardiac catheterization.
In normal subjects, the left ventricular ejection fraction (LVEF) should be about 50% [9] (range, 50-80%). There should be no area of abnormal wall motion (hypokinesis, akinesis or dyskinesis). Abnormalities in cardiac function may be manifested as a decrease in LVEF and/or the presence of abnormalities in global and regional wall motion.
Ejection fraction is given as a percentage with the normal range being between 50 and 75%. [60] The types are: Heart failure with reduced ejection fraction (HFrEF): Synonyms no longer recommended are "heart failure due to left ventricular systolic dysfunction" and "systolic heart failure". [61]
Reference ranges (reference intervals) for blood tests are sets of values used by a health professional to interpret a set of medical test results from blood samples. Reference ranges for blood tests are studied within the field of clinical chemistry (also known as "clinical biochemistry", "chemical pathology" or "pure blood chemistry"), the ...
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The standard definition of a reference range for a particular measurement is defined as the interval between which 95% of values of a reference population fall into, in such a way that 2.5% of the time a value will be less than the lower limit of this interval, and 2.5% of the time it will be larger than the upper limit of this interval, whatever the distribution of these values.
A transthoracic echocardiogram (TTE) is the most common type of echocardiogram, which is a still or moving image of the internal parts of the heart using ultrasound.In this case, the probe (or ultrasonic transducer) is placed on the chest or abdomen of the subject to get various views of the heart.