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Coronary artery stents, typically a metal framework, can be placed inside the artery to help keep it open. However, as the stent is a foreign object (not native to the body), it incites an immune response. This may cause scar tissue (cell proliferation) to rapidly grow over the stent and cause a neointimal hyperplasia.
For some high-risk cardiovascular patients with stents, the often-recommended practice of prolonged taking of aspirin might be ineffective, and in some cases, even harmful, a new study found.
Most current FDA-approved drug-eluting stents use sirolimus (also known as rapamycin), everolimus and zotarolimus. Biolimus A9-eluting stents, which utilize biodegradable polymers, are approved outside the U.S. [27] Newer-generation PCI technologies aim to reduce the risk of late stent thrombosis or other long-term adverse events.
Reduced blood flow to the heart associated with coronary ischemia can result in inadequate oxygen supply to the heart muscle. [6] When oxygen supply to the heart is unable to keep up with oxygen demand from the muscle, the result is the characteristic symptoms of coronary ischemia, the most common of which is chest pain. [6]
Duke Treadmill Score is a tool for predicting the risk of ischemia or infarction in the heart muscle. [1] The score is a function of data from an exercise test : [ citation needed ] [ 1 ] [exercise duration in minutes, by Bruce protocol ] – [ 5 × (maximal ST elevation or depression , in millimeters)] – [4 × (treadmill angina index)]
The Framingham Risk Score was first developed based on data obtained from the Framingham Heart Study, to estimate the 10-year risk of developing coronary heart disease. [1] In order to assess the 10-year cardiovascular disease risk, cerebrovascular events , peripheral artery disease and heart failure were subsequently added as disease outcomes ...
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