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2. Common sleep medication may prevent brain from clearing 'waste'

   www.aol.com/common-sleep-medication-may-prevent...

   In a mouse study, researchers found that zolpidem (Ambien), a common sleep aid, could prevent the brain from effectively clearing up 'waste', though it remains unclear whether this could affect ...

3. Macrogol - Wikipedia

   en.wikipedia.org/wiki/Macrogol

   Macrogol 4000, pharmaceutical quality. Macrogol 3350, often in combination with electrolytes, is used for short-term relief of constipation as well as for long-term use in constipation of various causes, including in multiple sclerosis and Parkinson's disease patients (an often-overlooked non-motor symptom) as well as constipation caused by pharmaceutical drugs such as opioids and ...

4. First pass effect - Wikipedia

   en.wikipedia.org/wiki/First_pass_effect

   [1] [2] The effect is most associated with orally administered medications, but some drugs still undergo first-pass metabolism even when delivered via an alternate route (e.g., IV, IM, etc.). [3] During this metabolism, drug is lost during the process of absorption which is generally related to the liver and gut wall. The liver is the major ...

5. Daridorexant - Wikipedia

   en.wikipedia.org/wiki/Daridorexant

   Daridorexant is indicated for the treatment of adults with insomnia characterized by difficulties with sleep onset and/or sleep maintenance. [1] The medication has been found to significantly improve latency to persistent sleep (LPS), wake after sleep onset (WASO), and subjective total sleep time (TST) in regulatory clinical trials. [1]

6. Methylphenidate - Wikipedia

   en.wikipedia.org/wiki/Methylphenidate

   The absorption is increased when the transdermal patch is applied onto inflamed skin or skin that has been exposed to heat. The absorption lasts for approximately 9 hours after application (onto normal, unexposed to heat and uninflamed skin). 90% of the medication is excreted in the urine as metabolites and unchanged drug. [76]

7. Nitrazepam - Wikipedia

   en.wikipedia.org/wiki/Nitrazepam

   [36] [37] Nitrazepam is commonly taken in overdose by drug abusers or suicidal individuals, sometimes leading to death. [38] [39] [40] Nitrazepam is teratogenic if taken in overdose during pregnancy with 30% of births showing congenital abnormalities. [41] It is a popular drug of abuse in countries where it is available. [42] [43] [44]

8. Exercise and deep sleep give the brain a 24-hour boost - AOL

   www.aol.com/exercise-deep-sleep-brain-24...

   Improvement to cognitive performance caused by exercise could last for 24 hours, a new study shows. Scientists also linked getting 6 or more hours of sleep to better memory test scores the next day.

9. Mirtazapine - Wikipedia

   en.wikipedia.org/wiki/Mirtazapine

   A 2012 review focused on antidepressants and sleep found that mirtazapine reduced the time it took to fall asleep and improved the quality of sleep in many people with sleep disorders caused by depression, but that it could also disturb sleep in many people, especially at higher doses, causing restless leg syndrome in 8 to 28% of people and in ...