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It may be used for the prophylaxis of cytomegalovirus disease associated with transplantation of kidney, lung, liver, pancreas, and heart. Alone or in combination with an antiviral agent, it has been shown to: Reduce the risk of CMV-related disease and death in some of the highest-risk transplant recipients
Maribavir, sold under the brand name Livtencity, is an antiviral medication that is used to treat post-transplant cytomegalovirus (CMV). [8] [9] Maribavir is a cytomegalovirus pUL97 kinase inhibitor that works by preventing the activity of human cytomegalovirus enzyme pUL97, thus blocking virus replication.
Cytomegalovirus (CMV) (from cyto-'cell' via Greek κύτος kútos - 'container' + μέγας mégas 'big, megalo-' + -virus via Latin vīrus 'poison') is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, [3] in the subfamily Betaherpesvirinae.
A Cytomegalovirus vaccine is a vaccine to prevent cytomegalovirus (CMV) infection or curb virus re-activation (symptomatic flare-ups) in persons already infected. Challenges in developing a vaccine include adeptness of CMV in evading the immune system and limited animal models. [ 1 ]
This includes patients receiving chemotherapy for cancer and patients on immune-suppressing medicines following an organ transplant. [ citation needed ] In rare instances, more severe CMV infection involving the gastrointestinal tract has been reported in people with a healthy immune system.
However, complete TCD via ex vivo, especially in acute myeloid leukemia (AML), patients usually does not improve survival. [7] In vivo depletion often uses monoclonal antibodies (eg, alemtuzumab) or heteroantisera. [7] In haploidentical hematopoietic stem cell transplantation, in vivo TCD suppressed lymphocytes early on. However, the incidence ...
Letermovir (INN; brand name Prevymis) is an antiviral drug for the treatment of cytomegalovirus (CMV) infections. It has been tested in CMV infected patients with allogeneic stem cell transplants and may also be useful for other patients with a compromised immune system such as those with organ transplants or HIV infections. [3]
The owl's eye appearance was considered rare for cytomegalovirus infection in the transplant, but was considered concerning. [18] The cytomegalovirus infection was found of relevance towards compromised immune patients, as previous cases show that immune problems for patients have a similar case of cytomegalovirus infection.