Ad
related to: mmp 13 enzyme blocker drugs classification guide free
Search results
Results From The WOW.Com Content Network
5-(spiropyrrolidin-5-yl)pyrimidinetrione is a compound named 848773-43-3 that is a potent MMP-2, MMP-9 and MMP-13 inhibitor that spares MMP-1 and TACE. By substituting 1,3,4-oxadiazol-2-yl heteroaryl at C-4’ of the diphenylether segment to accomplish MMP-13 selectivity over MT-1 MMP, made the compound 420121-84-2.
[5] [6] It is a member of the matrix metalloproteinase (MMP) family. Like most MMPs, it is secreted as an inactive pro-form. [7] MMP-13 has a predicted molecular weight around 54 kDa. [8] It is activated once the pro-domain is cleaved, leaving an active enzyme composed of the catalytic domain and the hemopexin-like domain . Although the actual ...
A matrix metalloproteinase inhibitor (INN stem –mastat [1]) inhibits matrix metalloproteinases.Because they inhibit cell migration, they have antiangiogenic effects. They are endogenous or exogenous.
The most commonly used groupings (by researchers in MMP biology) are based partly on historical assessment of the substrate specificity of the MMP and partly on the cellular localization of the MMP. These groups are the collagenases, the gelatinases, the stromelysins, and the membrane-type MMPs (MT-MMPs).
Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]
A notable class of kinase drug targets is the receptor tyrosine kinases which are essential enzymes that regulate cell growth; their over-activation may result in cancer. Hence kinase inhibitors such as imatinib are frequently used to treat malignancies. [97] Janus kinases are another notable example of drug enzyme targets.
Disulfiram-like drugs (2 C, 30 P) ... Oxidoreductase inhibitors (13 C, 9 P) R. ... Journal of Enzyme Inhibition and Medicinal Chemistry; K.
The MMP family is formed by twenty related zinc-dependent enzymes. They are noted for having the ability to degrade extracellular matrix proteins, such as collagens , laminin , and proteoglycans . These calcium- and zinc-dependent proteases are activated at neutral pH and twenty-three have been found present in mammalian cells.