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GLUT4 has a Km value for glucose of about 5 mM, which as stated above is the normal blood glucose level in healthy individuals. GLUT4 is the most abundant glucose transporter in skeletal muscle and is thus considered to be rate limiting for glucose uptake and metabolism in resting muscles. [8]
Binding of glucose to one site provokes a conformational change associated with transport, and releases glucose to the other side of the membrane. The inner and outer glucose-binding sites are, it seems, located in transmembrane segments 9, 10, 11; [ 8 ] also, the DLS motif located in the seventh transmembrane segment could be involved in the ...
Examples of molecules that follow this process are potassium K +, sodium Na +, and calcium Ca 2+. A place in the human body where this occurs is in the intestines with the uptake of glucose . Secondary active transport is when one solute moves down the electrochemical gradient to produce enough energy to force the transport of another solute ...
Metabolism (/ m ə ˈ t æ b ə l ɪ z ə m /, from Greek: μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms.The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks of proteins, lipids, nucleic acids, and some carbohydrates; and the ...
The sodium-glucose linked transporters (SGLTs) are responsible for the active transport of glucose across cell membranes. SGLT1 and SGLT2 are the most well-studied members of this family. [ 1 ] [ 2 ] Both SGLT1 and SGLT2 function as symporters , utilizing the energy from the sodium gradient created by the Na+/K+ ATPase to transport glucose ...
Glucose transporter type 4 (GLUT4), also known as solute carrier family 2, facilitated glucose transporter member 4, is a protein encoded, in humans, by the SLC2A4 gene. GLUT4 is the insulin -regulated glucose transporter found primarily in adipose tissues and striated muscle (skeletal and cardiac).
The glucose transporter (GLUTs) is a type of uniporter responsible for the facilitated diffusion of glucose molecules across cell membranes. [9] Glucose is a vital energy source for most living cells, however, due to its large size, it cannot freely move through the cell membrane. [16]
It is an integral membrane protein carrier with a hydrophilic interior, which allows it to bind to glucose. As GLUT 1 is a type of carrier protein, it will undergo a conformational change to allow glucose to enter the other side of the plasma membrane. [22] GLUT 1 is commonly found in the red blood cell membranes of mammals. [23]