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Neuromuscular-blocking drugs, or Neuromuscular blocking agents (NMBAs), block transmission at the neuromuscular junction, [1] causing paralysis of the affected skeletal muscles. This is accomplished via their action on the post-synaptic acetylcholine (Nm) receptors.
Drugs that interfere with nerve function, such as curare, can also cause paralysis. Pseudoparalysis ( pseudo- meaning "false, not genuine", from Greek ψεῦδος [ 7 ] ) is voluntary restriction or inhibition of motion because of pain, incoordination, orgasm, or other cause, and is not due to actual muscular paralysis. [ 8 ]
These poisons cause weakness of the skeletal muscles and, when administered in a sufficient dose, eventual death by asphyxiation due to paralysis of the diaphragm. In medicine, curare has been used as a treatment for tetanus and strychnine poisoning and as a paralyzing agent for surgical procedures.
Neuromuscular drugs are chemical agents that are used to alter the transmission of nerve impulses to muscles, causing effects such as temporary paralysis of targeted skeletal muscles. Most neuromuscular drugs are available as quaternary ammonium compounds which are derived from acetylcholine (ACh). [ 1 ]
In the process, metabolites, or byproducts, of the drug are produced, which can linger in our blood, urine (and even in our hair) for long after the initial effects of the drug are felt.
In children, the most common cause is a stroke of the ventral pons. [9]Unlike persistent vegetative state, in which the upper portions of the brain are damaged and the lower portions are spared, locked-in syndrome is essentially the opposite, caused by damage to specific portions of the lower brain and brainstem, with no damage to the upper brain.
Researchers found that several popular weight-loss drugs could cause rare but serious complications. Weight-loss drugs linked to stomach paralysis, study finds Skip to main content
Some reports say Ozempic and Mounjaro cause gastroparesis—but clinical trials do not. Doctors explain a potential link between weight loss drugs and stomach paralysis.