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The reactivity of ozone makes ozone a very general agent for killing pathogens given high enough concentration and time. When used in medical treatments the efficient targeting of ozone to the site where it needs to be active is therefor important. Non-targeted ozone at high concentrations could cause unwanted damage to healthy tissues.
However, the required concentrations are sufficiently toxic to humans and animals that the U.S. FDA declares that ozone has no place in medical treatment [10] and has taken action against businesses that offer ozone generators or ozone therapy to consumers. [11] Ozone is a highly toxic and extremely reactive gas. [12]
For seasonal affective disorder (SAD), a randomized controlled trial (RCT) comparing high (4.5x10 14 ions/second) and low (1.7x10 11 ions/second) flow rate negative air ionization with bright light therapy found that the post-treatment improvement percentage was 57.1% for bright light, 47.9% for high-density ions and 22.7% for low-density ions. [8]
The generators are usually ignited by a firing pin, and the chemical reaction is usually exothermic, making the generator a potential fire hazard. Potassium superoxide was used as an oxygen source on early crewed missions of the Soviet space program , in submarines for use in emergency situations, for firefighters , and for mine rescue .
UV ozone generators use ambient air for ozone production, no air prep systems are used (air dryer or oxygen concentrator), therefore these generators tend to be less expensive. However, UV ozone generators usually produce ozone with a concentration of about 0.5% or lower which limits the potential ozone production rate.
This resulted in damage to both bacterial cells and human tissue. Other sanitizing techniques, such as irrigation with antiseptics, were preferable. [40] [41] The psychoanalyst Wilhelm Reich was a proponent of ozone therapy, which was supposed to enhance an imaginary life force he called orgone.