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The HACEK organisms are a group of fastidious Gram-negative bacteria that are an unusual cause of infective endocarditis, which is an inflammation of the heart due to bacterial infection. [1] HACEK is an abbreviation of the initials of the genera of this group of bacteria: Haemophilus , Aggregatibacter (previously Actinobacillus ...
By far the most common cause of "culture-negative" endocarditis is prior administration of antibiotics and can occur in up to 31% of cases. [ 14 ] [ 7 ] Sometimes microorganisms can take a longer period of time to grow in the culture media, for example Cutibacterium spp. [ 15 ] and the HACEK bacteria group.
Eikenella corrodens is a Gram-negative facultative anaerobic bacillus that can cause severe invasive disease in humans. [1] It was first identified by M. Eiken in 1958, who called it Bacteroides corrodens. [2] E. corrodens is a rare pericarditis associated pathogen. [3]
Fastidious Gram-negative bacteria such as Cardiobacterium hominis along with Eikenella corrodens and Kingella kingae mainly inhabiting in the oral and upper respiratory tract in humans are responsible for 1–3% of infective endocarditis. [18] Treatment of the disease involves third-generation cephalosporin with more than 80-90% success rate. [18]
Endocarditis is an inflammation of the inner layer of the heart, the endocardium.It usually involves the heart valves.Other structures that may be involved include the interventricular septum, the chordae tendineae, the mural endocardium, or the surfaces of intracardiac devices.
Other strains of streptococci can cause subacute endocarditis as well. These include streptococcus intermedius, which can cause acute or subacute infection (about 15% of cases pertaining to infective endocarditis). [7] Enterococci from urinary tract infections and coagulase negative staphylococci can also be causative agents. [5]
Corynebacterium endocarditis usually infects the left side of the heart in males, though C. amycolatum has shown a predilection for women. [4] While cases of disease have been small in number, this underreporting could be due to misdiagnosis of C. amycolatum as C. xerosis, which is a known human pathogen. [2] [5]
Ceftriaxone, sold under the brand name Rocephin, is a third-generation cephalosporin antibiotic used for the treatment of a number of bacterial infections. [4] These include middle ear infections, endocarditis, meningitis, pneumonia, bone and joint infections, intra-abdominal infections, skin infections, urinary tract infections, gonorrhea, and pelvic inflammatory disease. [4]