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Screening should include calculation of the estimated GFR (eGFR) from the serum creatinine level, and measurement of urine albumin-to-creatinine ratio (ACR) in a first-morning urine specimen (this reflects the amount of a protein called albumin in the urine), as well as a urine dipstick screen for hematuria. [55]
Cat with chronic kidney disease and typical symptoms: fatigue, emaciation and dull, shaggy coat. The chronic kidney disease of the cat (CKD or CNE) – also called chronic renal insufficiency (CRI or CNI) or chronic renal failure (CRF) in the older literature – is an incurable, progressive disease characterized by a gradual decrease in the nephrons and thus to a decreasing function ...
Cushing's is an umbrella term for conditions caused by elevated cortisol and adrenocorticotropic hormone levels. Cushing's disease most commonly refers to pituitary-dependent hyperadrenocorticism, the most common condition of Cushing's syndrome, but 'Cushing's' is used to refer to all hyperadrenocorticism conditions.
This results in lower levels of urea in the blood and higher levels of urea in the urine as compared to creatinine. Creatinine filtration decreases, leading to a higher amount of creatinine in the blood. Third-spacing of fluids, as in peritonitis, osmotic diuresis, or low aldosterone states such as Addison's disease all elevate urea. [3]
An increase in serum creatinine can be due to increased ingestion of cooked meat (which contains creatinine converted from creatine by the heat from cooking) or excessive intake of protein and creatine supplements, taken to enhance athletic performance. Intense exercise can increase creatinine by increasing muscle breakdown.
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Kidney failure, also known as renal failure or end-stage renal disease (ESRD), is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. [2]