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It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...
The sale of mouse animal models began in 1933 with early sales to the United States Public Health Service and The Jackson Laboratory now provides a high proportion of the mice used in biomedical research [16] In particular, the C57BL/6J strain, which is widely used and cited is maintained at The Jackson Laboratory.
While studying under W. E. Castle, Little began his work with mice, focusing on inheritance, transplants, and grafts. He also was an assistant dean and secretary to the president. In 1921, he inbred the mouse strain C57BL/6 or "black 6", which is the most popular laboratory mouse to date. [2]
Unlike most laboratory mouse strains, the C57BL/6 drinks alcoholic beverages voluntarily. It is more susceptible than average to morphine addiction, atherosclerosis, and age-related hearing loss. [11] When compared directly to BALB/c mice, C57BL/6 mice also express both a robust response to social rewards [43] [44] and empathy. [45]
All laboratories using vertebrate lab animals in the United States are required by law to have a licensed veterinarian on staff and to adhere to the NIH Guide for the Use and Care of Laboratory Animals, which further stipulates that all protocols, including the sources for obtaining the animals, must be reviewed by an independent committee. [6]
Mouse Genome Informatics (MGI) is a free, online database and bioinformatics resource hosted by The Jackson Laboratory, with funding by the National Human Genome Research Institute (NHGRI), the National Cancer Institute (NCI), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). [1]
The genetically modified mouse in which a gene affecting hair growth has been knocked out (left) shown next to a normal lab mouse. A genetically modified mouse, genetically engineered mouse model (GEMM) [1] or transgenic mouse is a mouse (Mus musculus) that has had its genome altered through the use of genetic engineering techniques.
Mus musculus B16F10 skin melanoma cells in laboratory. B16 melanoma is a murine tumor cell line used for research as a model for human skin cancers. B16 cells are useful models for the study of metastasis and solid tumor formation, and were one of the first effective murine tools for metastasis research. These cells readily metastasize to lymph ...