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Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. It works by inhibiting the production of prostaglandins , endogenous signaling molecules known to cause these symptoms.
Urinary tract infection in pediatric patients is a significant clinical issue, affecting approximately 7% of fevered infants and children. [43] If left untreated, the infection can ascend from the bladder to the kidneys, resulting in acute pyelonephritis, which leads to hypertension , kidney scarring , and end-stage kidney disease .
Bacteria and yeast, including those naturally occurring as part of the human microbiome, can grow within biofilm that forms along the surface of urinary catheters. This leads to infection in the bladder, kidneys, and other organs connected to the urinary tract.
Indometacin farnesil is a prodrug of the nonsteroidal anti-inflammatory drug (NSAID) indometacin, [1] designed to reduce the occurrence of side-effects by esterification of the carboxyl group on indometacin with farnesol.
Knowing the indication of the drug can also help providers determine if the dose of the drug is appropriate per indication, and this can greatly improve patient safety and drug effectiveness. [ 28 ] However, there are still some challenges with incorporating the indication of use on prescription drug labels.
Common indications for urinary catheterization include acute or chronic urinary retention (which can damage the kidneys) from conditions such as benign prostatic hyperplasia, orthopedic procedures that may limit a patient's movement, the need for accurate monitoring of input and output (such as in an ICU), urinary incontinence that may compromise the ability to heal wounds, and the effects of ...