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Idiopathic multicentric Castleman disease (iMCD) is a subtype of Castleman disease (also known as giant lymph node hyperplasia, lymphoid hamartoma, or angiofollicular lymph node hyperplasia), a group of lymphoproliferative disorders characterized by lymph node enlargement, characteristic features on microscopic analysis of enlarged lymph node tissue, and a range of symptoms and clinical findings.
men who have sex with men MSMW men who have sex with men and women: MSO 4: morphine sulfate (Do not use this abbreviation. Write out the name. Per the do-not-use list.) MSOF: multisystem organ failure: MSSA: methicillin-sensitive Staphylococcus aureus (contrast with MRSA) MSU: midstream urine sample (used in testing for presence of urinary ...
Cancer: CACH Childhood ataxia with central nervous system hypomyelination (see vanishing white matter disease) CAD Coronary artery disease: CADASIL: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy CAP Community acquired pneumonia: CAPA COVID-19–associated pulmonary aspergillosis CAPD
Though all forms of MCD involve excessive production of cytokines and a cytokine storm, iMCD has important differences in symptoms, disease course, and treatment from POEMS-associated MCD and HHV-8-associated MCD. First line treatment for iMCD is anti-IL-6 therapy with siltuximab (or tocilizumab, if siltuximab is not available).
Doxorubicin (adriamycin), bleomycin, vinblastine, dacarbazine (first-line treatment for Hodgkin's lymphoma) ABX: antibiotics: a.c. AC: before a meal (from Latin ante cibum) AC: abdominal circumference assisted controlled ventilation acromioclavicular joint antecubital fossa: ACA: acinic cell carcinoma Affordable Care Act. anterior cerebral ...
FMTC = familial medullary thyroid cancer Micrograph of a medullary thyroid carcinoma, as may be seen in MEN 2A and MEN 2B. H&E stain. MEN 2B is sometimes known as MEN 3 and the designation varies by institution (c.f. www.ClinicalReview.com). Although a variety of additional eponyms have been proposed for MEN2B (e.g. Williams-Pollock syndrome ...
The term "induction regimen" refers to a chemotherapy regimen used for the initial treatment of a disease. A "maintenance regimen" refers to the ongoing use of chemotherapy to reduce the chances of a cancer recurring or to prevent an existing cancer from continuing to grow. [2]
MCD is involved in regulating cardiac malonyl-CoA levels, inhibition of MCD can limit rates of fatty acid oxidation, leading to a secondary increase in glucose oxidation associated with an improvement in the functional recovery of the heart during ischaemia/reperfusion injury. MCD is a potential novel target for cancer treatment.