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Such illness responses include lethargy, depression, anxiety, malaise, loss of appetite, [3] [4] sleepiness, [5] hyperalgesia, [6] reduction in grooming [1] [7] and failure to concentrate. [8] Sickness behavior is a motivational state that reorganizes the organism's priorities to cope with infectious pathogens.
After going through stages of REM-sleep, people with depression report feeling better, in a study done by Cartwright et al. [40] Conversely, a theory proposed by Revonsuo [41] states that when people experience negative emotions or negative events, when they sleep the REM-sleep replays such events, which is known as rehearsal. [39]
A general lack of energy, fatigue, and tiredness that cannot be otherwise explained is also a symptom of a major depressive episode. [3] A person may feel tired without engaging in any physical activity, which may cause day-to-day tasks, such as showering, to become unmanageable. [10]
The symptoms of anxiety and depression disorders can be very similar. A diagnosis of mixed anxiety–depressive disorder as opposed to a diagnosis of depression or an anxiety disorder can be difficult. Due to this, it has long been a struggle to find a singular set of criteria to use in the diagnosis of mixed-anxiety depressive disorder. [3]
Of course, if you're feeling sick, ... Diarrhea “These variants still have the potential to cause severe disease,” Russo says.
"Depression with anxious distress" was added into the DSM-5 as a means to emphasize the common co-occurrence between depression or mania and anxiety, as well as the risk of suicide of depressed individuals with anxiety. Specifying in such a way can also help with the prognosis of those diagnosed with a depressive or bipolar disorder.